2-羟基-5-甲氧基苯甲醛合成路线 （共 150 条）
反应条件
1: 73 percent / acetonitrile / 2 h
2: 66 percent / pyridine / CHCl3 / 0.5 h / Heating
3: 71 percent / triethylamine / toluene / 2 h / Heating
View Scheme
参考文献
Guillaumel; Royer; Le Corre; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 431 - 436
反应条件
1: 73 percent / acetonitrile / 2 h
2: 71 percent / pyridine / CHCl3 / 2 h / Heating
3: 74 percent / triethylamine / toluene / 1.25 h / Heating
View Scheme
参考文献
Guillaumel; Royer; Le Corre; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 431 - 436
反应条件
1: 73 percent / acetonitrile / 2 h
2: 78 percent / pyridine / CHCl3 / 7 h / Heating
3: 77 percent / triethylamine / toluene / 1 h / Heating
View Scheme
参考文献
Guillaumel; Royer; Le Corre; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 431 - 436
反应条件
in methanol
T=20°C; 23 h;
参考文献
Guillaumel; Royer; Le Corre; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 431 - 436
反应条件
1: 61 percent / HNO3 (d = 1.42) / acetic acid / 1 h / 10 °C
2: 91 percent / Ag2O / CHCl3 / 1.5 h / Heating
View Scheme
参考文献
Rubenstein
Journal of the Chemical Society, 1925 , vol. 127, p. 2003
参考文献
Ohta, Hiromi; Harada, Kenji; Irie, Koji; Kashino, Setsuo; Kambe, Takashi; Sakane, Genta; Shibahara, Takashi; Takamizawa, Satoshi; Mori, Wasuke; Nonoyama, Matsuo; Hirotsu, Masakazu; Kojima, Masaaki
Chemistry Letters, 2001 , # 8 p. 842 - 843
反应条件
1: potassium carbonate / acetone / |Inert atmosphere
2: methanol / 48 h / 20 °C / |Inert atmosphere
3: sodium tetrahydroborate / methanol / 1 h / 0 °C / |Inert atmosphere
4: palladium diacetate; copper diacetate / toluene / |Reflux
5: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 4 h / 20 °C / 2068.65 Torr
View Scheme
参考文献
Lim, Hye Sun; Choi, Young Lok; Heo, Jung-Nyoung
Organic Letters, 2013 , vol. 15, # 18 p. 4718 - 4721
反应条件
dibutylamine in chloroform
T=80°C; 24 h;
参考文献
Neirabeyeh, Mamdouh Al; Koussini, Rafik
Synthetic Communications, 1990 , vol. 20, # 6 p. 783 - 788
反应条件
phthalic anhydride; dibutylamine in toluene
Heating;
参考文献
Viaud; Mamai; Guerin; Bennejean; Renard; Delagrange; Guardiola-Lemaitre; Howell; Guillaumet
Pharmacy and Pharmacology Communications, 1998 , vol. 4, # 1 p. 47 - 56
反应条件
1: 33 percent / K2CO3 / dimethylformamide / 80 °C
2: 39 percent / BBr3 / CH2Cl2 / 20 °C
View Scheme
参考文献
Haning, Helmut; Mueller, Ulrich; Schmidt, Gunter; Schmeck, Carsten; Voehringer, Verena; Kretschmer, Axel; Bischoff, Hilmar
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 3992 - 3996
