2-羟基-5-异丙基-2,4,6-环庚三烯-1-酮合成路线 （共 16 条）
参考文献
Mori, Akira; Yokoo, Hiroki; Hatsui, Toshihide
Tetrahedron, 2004 , vol. 60, # 40 p. 8783 - 8790
参考文献
Erdtman; Gripenberg
Acta Chemica Scandinavica (1947-1973), 1948 , vol. 2, p. 625,635
参考文献
Erdtman; Gripenberg
Acta Chemica Scandinavica (1947-1973), 1948 , vol. 2, p. 625,635
反应条件
1: With PHT in tetrahydrofuran
T=20°C; Bromination; 1 h;
2: With lithium carbonate; lithium bromide in N,N-dimethyl-formamide
Aromatisation; 2 h; Heating;
参考文献
Soung, Min-Gyu; Matsui, Masanao; Kitahara, Takeshi
Tetrahedron, 2000 , vol. 56, # 39 p. 7741 - 7745
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Nozoe,T. et al.
Bulletin of the Chemical Society of Japan, 1960 , vol. 33, p. 1452 - 1458
反应条件
1: aq. NaOH / ethanol
2: H2 / Pd-C / ethanol
View Scheme
参考文献
Nozoe,T. et al.
Bulletin of the Chemical Society of Japan, 1960 , vol. 33, p. 1452 - 1458
反应条件
1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -15 - 0 °C
1.2: tetrahydrofuran; hexane / 2 h / -78 - 20 °C
2.1: TiCl4 / CH2Cl2 / 0.17 h / -78 °C
3.1: HMDS / CH2Cl2 / 4 h / -78 - 20 °C
4.1: MCPBA / hexane / 4 h / 20 °C
4.2: 0.4 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
5.1: 94 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
6.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
6.2: 75 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Soung, Min-Gyu; Matsui, Masanao; Kitahara, Takeshi
Tetrahedron, 2000 , vol. 56, # 39 p. 7741 - 7745
反应条件
1.1: 94 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
2.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
2.2: 75 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Soung, Min-Gyu; Matsui, Masanao; Kitahara, Takeshi
Tetrahedron, 2000 , vol. 56, # 39 p. 7741 - 7745
反应条件
1.1: HMDS / CH2Cl2 / 4 h / -78 - 20 °C
2.1: MCPBA / hexane / 4 h / 20 °C
2.2: 0.4 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
3.1: 94 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
4.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
4.2: 75 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Soung, Min-Gyu; Matsui, Masanao; Kitahara, Takeshi
Tetrahedron, 2000 , vol. 56, # 39 p. 7741 - 7745
反应条件
1.1: MCPBA / hexane / 4 h / 20 °C
1.2: 0.4 g / Et3N*3HF / CH2Cl2 / 2 h / 20 °C
2.1: 94 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
3.1: pyrrolidone hydrotribromide / tetrahydrofuran / 1 h / 20 °C
3.2: 75 percent / LiBr; Li2CO3 / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Soung, Min-Gyu; Matsui, Masanao; Kitahara, Takeshi
Tetrahedron, 2000 , vol. 56, # 39 p. 7741 - 7745
