4-甲氧基-6-甲基-2H-吡喃酮合成路线 （共 57 条）
反应条件
titanium tetrachloride in dichloromethane T=-10 - 20°C; 24 h; Yield given;
参考文献
Shimizu, Takeshi; Hiranuma, Sayoko; Watanabe, Tsumoru; Kirihara, Masayuki
Heterocycles, 1994 , vol. 38, # 2 p. 243 - 248
反应条件
titanium tetrachloride in dichloromethane T=-10 - 20°C; 24 h;
参考文献
Shimizu, Takeshi; Hiranuma, Sayoko; Watanabe, Tsumoru; Kirihara, Masayuki
Heterocycles, 1994 , vol. 38, # 2 p. 243 - 248
反应条件
T=200°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger, Franz; Ziegler, Thomas
Chemische Berichte, 1987 , vol. 120, p. 1339 - 1346
反应条件
1: methanol; magnesium / 6 h / Inert atmosphere; Reflux 2: palladium 10 on activated carbon; hydrogen / methanol; chloroform / 2 h View Scheme
参考文献
McCracken, Stephen T.; Kaiser, Marcel; Boshoff, Helena I.; Boyd, Peter D.W.; Copp, Brent R.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 4 p. 1482 - 1493
反应条件
1: selenium(IV) oxide / 1,4-dioxane / 5 h / 180 °C / Inert atmosphere; Sealed tube 2: n-butyllithium; triphenyl-methyl-phosphonium iodide / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere 3: sodium acetate; palladium diacetate / acetonitrile / 0.17 h 4: 5 Pd(II)/C(eggshell); hydrogen / methanol / 1.5 h / 20 °C View Scheme
参考文献
Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.
European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
反应条件
magnesium methanolate in methanol 7 h; Heating;
参考文献
Adam; Saha-Moller; Veit; Welke
Synthesis, 1994 , # 11 p. 1133 - 1134
反应条件
1: selenium(IV) oxide / 1,4-dioxane / 5 h / 180 °C / Inert atmosphere; Sealed tube 2: n-butyllithium; triphenyl-methyl-phosphonium iodide / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere 3: sodium acetate; palladium diacetate / acetonitrile / 0.17 h View Scheme
参考文献
Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.
European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
反应条件
sodium methylate in methanol T=185°C; 0.5 h;
参考文献
Effenberger, Franz; Schoenwaelder, Karl-Heinz
Chemische Berichte, 1984 , vol. 117, # 11 p. 3270 - 3279
反应条件
1: methyl 2,4-dimethoxy-6-methylbenzoate With lithium diisopropyl amide in tetrahydrofuran; cyclohexane
T=-78°C; 0.333333 h;
2: 4-methoxy-6-methyl-2H-pyran-2-one in tetrahydrofuran; cyclohexane
T=-78 - 20°C;
参考文献
Zhang, Zhaojun; Yu, Biao
Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6309 - 6313
反应条件
1: 2,4-dimethoxy-6-methylbenzoic acid methyl ester With lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
2: 4-methoxy-6-methyl-2H-pyran-2-one in tetrahydrofuran
T=-78 - 20°C; Staunton-Weinreb annulation;
参考文献
Wadsworth, Andrew D.; Sperry, Jonathan; Brimble, Margaret A.
Synthesis, 2010 , # 15 art. no. P05810SS, p. 2604 - 2608
