3,3-二甲基-1-苯基-2-丁酮合成路线 （共 50 条）
反应条件
1: (i) NaNHNH2, (ii) H2O
2: aq. AcOH
3: aq. H2SO4
View Scheme
参考文献
Kauffmann,T.; Sobel,J.
Chemische Berichte, 1966 , vol. 99, p. 1843 - 1850
反应条件
(electrochemical reduction);
参考文献
Shono,T. et al.
Chemistry Letters, 1977 , p. 1021 - 1024
反应条件
potassium tert-butylate; iron(III) chloride
other aryl halides and ketones; other reagents; multistep reaction; Product distributionMechanism;
参考文献
Galli, Carlo; Gentili, Patrizia
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 6 p. 1135 - 1140
参考文献
Lenoir, Dieter; Burghard, Harald
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4715 - 4725
反应条件
1: 1.) LDA / 1.) THF, ether, -78 deg C, 2.) reflux, 30 min
2: 96 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / 2 h / -10 °C
View Scheme
参考文献
Creary,X.; Geiger,C.C.
Journal of the American Chemical Society, 1982 , vol. 104, p. 4151
反应条件
bromine in water
T=20°C; 4 h;
参考文献
Montignoul, Claude; Richard, Marie-Josee; Vigne, Christian; Giral, Louis
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1509 - 1519
反应条件
bromine; magnesium in tetrachloromethane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
Bayer Aktiengesellschaft
Patent: US4002763 A1, 1977 ;
反应条件
2,2,2-tribromo-2,2-dihydrobenzo-1,3,2-dioxaphosphole in chloroform
T=70°C; 2 h;
参考文献
Von Roman; Ruhdorfer; Knorr
Synthesis, 1993 , # 10 p. 985 - 992
反应条件
1: 1.) LDA / 1.) THF, ether, -78 deg C, 2.) reflux, 30 min
2: 96 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / 2 h / -10 °C
3: 524 mg / CF3COOH / methanol / 4 h / Heating
4: NaOCH3 / methanol / 8 h / Heating
View Scheme
参考文献
Creary,X.; Geiger,C.C.
Journal of the American Chemical Society, 1982 , vol. 104, p. 4151
反应条件
1: 1.) LDA / 1.) THF, ether, -78 deg C, 2.) reflux, 30 min
2: 96 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / 2 h / -10 °C
3: 524 mg / CF3COOH / methanol / 4 h / Heating
View Scheme
参考文献
Creary,X.; Geiger,C.C.
Journal of the American Chemical Society, 1982 , vol. 104, p. 4151
