(R)-N-叔丁氧羰基-1-[4-(叔-丁基二甲基硅烷基氧基甲基)环己基]乙烷-1-胺合成路线 （共 8 条）
反应条件
1: TBAF / tetrahydrofuran / 0 °C 2: TEMPO; NaClO2; NaOCl / aq. phosphate buffer / acetonitrile / 35 °C 3: TBTU; DIEA / dimethylformamide / 20 °C View Scheme
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
反应条件
1: 61 percent / Et3N; DMAP
2: 80 percent / PCC / CH2Cl2
3: MgSO4 / CH2Cl2
4: CuI; BF3*Et2O / tetrahydrofuran / -65 - -30 °C
5: HCO2NH4; Pd/C / methanol / Heating
6: aq. NaHCO3; Na2CO3 / 1,2-dimethoxy-ethane
View Scheme
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
反应条件
1: 61 percent / Et3N; DMAP
2: 80 percent / PCC / CH2Cl2
3: MgSO4 / CH2Cl2
4: CuI; BF3*Et2O / tetrahydrofuran / -65 - -30 °C
5: HCO2NH4; Pd/C / methanol / Heating
6: aq. NaHCO3; Na2CO3 / 1,2-dimethoxy-ethane
View Scheme
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
反应条件
1: 80 percent / PCC / CH2Cl2
2: MgSO4 / CH2Cl2
3: CuI; BF3*Et2O / tetrahydrofuran / -65 - -30 °C
4: HCO2NH4; Pd/C / methanol / Heating
5: aq. NaHCO3; Na2CO3 / 1,2-dimethoxy-ethane
View Scheme
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
反应条件
1: MgSO4 / CH2Cl2
2: CuI; BF3*Et2O / tetrahydrofuran / -65 - -30 °C
3: HCO2NH4; Pd/C / methanol / Heating
4: aq. NaHCO3; Na2CO3 / 1,2-dimethoxy-ethane
View Scheme
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
反应条件
1: CuI; BF3*Et2O / tetrahydrofuran / -65 - -30 °C
2: HCO2NH4; Pd/C / methanol / Heating
3: aq. NaHCO3; Na2CO3 / 1,2-dimethoxy-ethane
View Scheme
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
反应条件
1: HCO2NH4; Pd/C / methanol / Heating
2: aq. NaHCO3; Na2CO3 / 1,2-dimethoxy-ethane
View Scheme
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
反应条件
sodium hydrogencarbonate; sodium carbonate in ethylene glycol dimethyl ether
参考文献
Gingras, Karine; Avedissian, Hovsep; Thouin, Eryk; Boulanger, Veronique; Essagian, Charles; McKerracher, Lisa; Lubell, William D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4931 - 4934
