4-(1,3-噻唑-2-基)苯甲腈合成路线 （共 5 条）
反应条件
sodium carbonate; palladium triphenylphosphine in water; acetonitrile T=90°C; 24 h; Inert atmosphereSealed tube;
参考文献
AB SCIENCE; MOUSSY, Alain; BENJAHAD, Abdellah; MARTIN, Jason; CHEVENIER, Emmanuel; PEZ, Didier; SANDRINELLI, Franck; PICOUL, Willy
Patent: WO2011/86085 A1, 2011 ;
Location in patent: Page/Page column 61-62 ;
WO 2011/086085 A1
反应条件
1: 1,3-thiazole With n-butyllithium in tetrahydrofuran T=-78°C; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 20°C; 1.5 h; Inert atmosphere; 3: para-chloro-benzonitrile With Pd-PEPPSI-IPent in tetrahydrofuran T=60°C; Negishi coupling; 24 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
1: 2-Methylthio-1,3-thiazole With 3-chloroprop-1-ene; trifluoroacetic acid; cobalt(II) dibromide; zinc in acetonitrile T=35°C; 2: para-iodobenzonitrile With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide; acetonitrile T=35°C; Barbier type reaction;
参考文献
Begouin, Jeanne-Marie; Rivard, Michael; Gosmini, Corinne
Chemical Communications, 2010 , vol. 46, # 32 p. 5972 - 5974
反应条件
1: sodium acetate / 80 °C 2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 9 h / 20 °C / |Molecular sieve View Scheme
参考文献
Chemistry - An Asian Journal, , vol. 8, # 7 p. 1408 - 1411
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane Stille coupling; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 10 p. 3551 - 3558
