<b>Multi-step reaction with 3 steps<br /> </b>1: 90 percent / NaOEt / diethyl ether / 1) 4 h, 0 deg C, 2) 12 h, room temperature<br />2: 53 percent / 1) 150 min, 260-263 deg C, 2) 40 deg C, 3) ethanol, 0 deg C<br />3: 95 percent / KOH / ethanol; H₂O / 17 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 53 percent / 1) 150 min, 260-263 deg C, 2) 40 deg C, 3) ethanol, 0 deg C<br />2: 95 percent / KOH / ethanol; H₂O / 17 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 95 percent / N,N-Dimethylaniline / 0.75 h / 100 &deg;C<br />2: 96 percent / PCl₅ / 1) 3 h, room temperature, 2) 1 h, 100 deg C<br />3: 90 percent / NaOEt / diethyl ether / 1) 4 h, 0 deg C, 2) 12 h, room temperature<br />4: 53 percent / 1) 150 min, 260-263 deg C, 2) 40 deg C, 3) ethanol, 0 deg C<br />5: 95 percent / KOH / ethanol; H₂O / 17 h / Heating<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11326756', constants.ctx, '0')">(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11343411', constants.ctx, '0')">tris-(dibenzylideneacetone)dipalladium⁽⁰⁾</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8402623', constants.ctx, '0')">sodium t-butanolate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />Buchwald-Hartwig Coupling;&nbsp;<br /> &nbsp;