1,4-二氯-5,6,7,8-四氢二氮杂萘合成路线 （共 3 条）
反应条件
trichlorophosphate
1 h; Heating / reflux;
参考文献
NOVARTIS AG
Patent: WO2008/110611 A1, 2008 ;
Location in patent: Page/Page column 104 ;
反应条件
in toluene
1 h; Heating;
参考文献
Sparey, Tim J.; Harrison, Timothy
Tetrahedron Letters, 1998 , vol. 39, # 32 p. 5873 - 5874
反应条件
1: sodium acetate; NH2NH2•xH2O / acetic acid / 16 h / 100 °C
2: trichlorophosphate / 16 h / Reflux
View Scheme
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); GARCIA COLLAZO, Ana Maria; PASTOR FERNANDEZ, Joaquin; BLANCO APARICIO, Carmen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco Javier; HERNANDEZ HIGUERAS, Ana Isabel; SALUSTE, Carl-Gustave Pierre; GONZALEZ CANTALAPIEDRA, Esther; MARTINEZ GONZALEZ, Sonia; SALGADO SERRANO, Antonio; NOYA MARINO, Beatriz
Patent: WO2011/80510 A1, 2011 ;
WO 2011/080510 A1
