1-甲氧基-1H-吲哚-3-甲醛合成路线 （共 38 条）
反应条件
1: 1,1-dimethylallyl alcohol With potassium hydride in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; 0.166667 h; 2: daikon-phytoalexin in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; 1 h; regioselective reaction;
参考文献
Yamada, Fumio; Shinmyo, Daisuke; Nakajou, Masahiro; Somei, Masanori
Heterocycles, 2012 , vol. 86, # 1 p. 435 - 453
反应条件
water; potassium iodide in N,N-dimethyl-formamide T=160°C; 24 h;
参考文献
Somei, Masanori; Sayama, Shinsuke; Naka, Katsumi; Shinmoto, Kotaro; Yamada, Fumio
Heterocycles, 2007 , vol. 73, # C p. 537 - 554
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Yamada, Fumio; Shinmyo, Daisuke; Nakajou, Masahiro; Somei, Masanori
Heterocycles, 2012 , vol. 86, # 1 p. 435 - 453
反应条件
1: 96 percent / 2n NaOH 2: 16 percent / H2 / 10percent Pd-C / CHCl3 View Scheme
参考文献
Somei; Ohnishi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 5147 - 5148
反应条件
pyridine; lithium aluminium tetrahydride; hydroxylamine hydrochloride Yield given. Multistep reaction;
参考文献
Kawasaki, Toshiya; Somei, Masanori
Heterocycles, 1990 , vol. 31, # 9 p. 1605 - 1608
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
Vilsmeier-Haack Formylation; Cooling with ice;
2: 1-methoxyindole T=20°C; Vilsmeier-Haack Formylation; 3 h;
3: With sodium hydroxide in water
Vilsmeier-Haack Formylation; Cooling with ice;
参考文献
Vo, Quan V.; Trenerry, Craige; Rochfort, Simone; Wadeson, Jenny; Leyton, Carolina; Hughes, Andrew B.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 856 - 864
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 0.333333 h;
参考文献
Selvakumar; Rajulu, G. Govinda
Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4429 - 4432
参考文献
Kawasaki, Toshiya; Kodama, Atsushi; Nishida, Tokiko; Shimizu, Kazuhisa; Somei, Masanori
Heterocycles, 1991 , vol. 32, # 2 p. 221 - 227
反应条件
1: tri(n-octyl)methylammonium chloride, 10 percent aq. NaOH / diethyl ether; H2O / 21 h / Ambient temperature
2: 91.3 percent / phosphorus oxychloride / 2 h / Ambient temperature
View Scheme
参考文献
Somei; Ohnishi; Shoken
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 677 - 681
反应条件
1: 79 percent / potassium carbonate / tetrahydrofuran / 36 h / 0 - 20 °C
2: 60 percent / NaCl / dimethylsulfoxide / 0.33 h / 150 °C
3: 80 percent / LiOH / dimethylformamide; H2O / 0 - 20 °C
4: 88 percent / copper; quinoline / 0.33 h / 220 °C
5: 98 percent / DIBAL-H / toluene / 0.33 h / -78 °C
View Scheme
参考文献
Selvakumar; Rajulu, G. Govinda
Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4429 - 4432
