(R)-6-氯-1-苯基-2,3,4,5-四氢-1H-苯并[d]氮杂卓-7,8-二醇氢溴酸合成路线 （共 13 条）
反应条件
1: aq. HCl / acetic acid / 100 °C
2: 90 percent / boron tribromide / CH2Cl2; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h
View Scheme
参考文献
Neumeyer, John L.; Baindur, Nandkishore; Niznik, Hyman B.; Guan, H. C.; Seeman, Philip
Journal of Medicinal Chemistry, 1991 , vol. 34, # 12 p. 3366 - 3371
反应条件
1: 3.1 g / benzene / 3 h / 60 °C
2: aq. HCl / acetic acid / 100 °C
3: 90 percent / boron tribromide / CH2Cl2; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h
View Scheme
参考文献
Neumeyer, John L.; Baindur, Nandkishore; Niznik, Hyman B.; Guan, H. C.; Seeman, Philip
Journal of Medicinal Chemistry, 1991 , vol. 34, # 12 p. 3366 - 3371
反应条件
1: 1.) n-BuLi, 2.) hexachloroethane / 1.) Et2O, THF, -70 deg C, 10 min, 2.) Et2O, THF, -70 deg C, 5 min
2: 3.1 g / benzene / 3 h / 60 °C
3: aq. HCl / acetic acid / 100 °C
4: 90 percent / boron tribromide / CH2Cl2; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h
View Scheme
参考文献
Neumeyer, John L.; Baindur, Nandkishore; Niznik, Hyman B.; Guan, H. C.; Seeman, Philip
Journal of Medicinal Chemistry, 1991 , vol. 34, # 12 p. 3366 - 3371
