6-氯-2,3,4,5-四氢-7,8-二甲氧基-1-(4-甲氧基苯基)-1H-3-苯并氮杂卓合成路线 （共 19 条）
反应条件
sodium hydroxide in CF3 COOH; chloroform
参考文献
Eisai Co., Ltd.
Patent: US5292521 A1, 1994 ;
反应条件
sulfuric acid; trifluoroacetic acid T=25°C; 3.5 h;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 19 percent / 2.5 h / Heating 2: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 2: 19 percent / 2.5 h / Heating 3: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 90 percent / Cl2 2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 4: 97 percent / 12N aq. HCl 5: 96 percent / dimethylsulfoxide / 1.25 h 6: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 7: 19 percent / 2.5 h / Heating 8: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 96 percent / dimethylsulfoxide / 1.25 h 2: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 3: 19 percent / 2.5 h / Heating 4: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 2: 97 percent / 12N aq. HCl 3: 96 percent / dimethylsulfoxide / 1.25 h 4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 5: 19 percent / 2.5 h / Heating 6: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 3: 97 percent / 12N aq. HCl 4: 96 percent / dimethylsulfoxide / 1.25 h 5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 6: 19 percent / 2.5 h / Heating 7: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 97 percent / 12N aq. HCl 2: 96 percent / dimethylsulfoxide / 1.25 h 3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 4: 19 percent / 2.5 h / Heating 5: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 40 percent / BH3 / tetrahydrofuran / 0.5 h / Heating 2: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
