6-氯-2,3,4,5-四氢-7,8-二甲氧基-1-(4-甲氧基苯基)-1H-3-苯并氮杂卓合成路线 （共 19 条）
反应条件
1: 86.4 percent / Br2 / CH2Cl2 / -5 - 0 °C 2: 95 percent / MgSO4, MgO / 1.25 h / Heating 3: K2CO3 / dimethylformamide / 2 h / 110 °C 4: 10percent aq. H2SO4 / Heating 5: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 95 percent / MgSO4, MgO / 1.25 h / Heating 2: K2CO3 / dimethylformamide / 2 h / 110 °C 3: 10percent aq. H2SO4 / Heating 4: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: K2CO3 / dimethylformamide / 2 h / 110 °C 2: 10percent aq. H2SO4 / Heating 3: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: pyridine, 12 N aq. HCl, tert-butylhydroquinone / 1.5 h / 125 °C 2: 86.4 percent / Br2 / CH2Cl2 / -5 - 0 °C 3: 95 percent / MgSO4, MgO / 1.25 h / Heating 4: K2CO3 / dimethylformamide / 2 h / 110 °C 5: 10percent aq. H2SO4 / Heating 6: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 19 percent 2: 68 percent / H2SO4 / trifluoroacetic acid / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975
反应条件
1: Heating 2: B2H6 / tetrahydrofuran 3: 68 percent / H2SO4 / trifluoroacetic acid / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 9 p. 973 - 975
反应条件
1: 10percent aq. H2SO4 / Heating 2: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
boron tribromide in dichloromethane T=25°C; 3 h;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
boron tribromide in dichloromethane
参考文献
Weinstock; Wilson; Ladd; Brush; Pfeiffer; Kuo; Holden; Yim; Hahn; Wardell Jr.; Tobia; Setler; Sarau; Ridley
Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 973 - 975
