2,3,4,5-四氢苯并[c]氮杂-1-酮合成路线 （共 23 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 24 h; Heating;
参考文献
Meyers, A. I.; Hutchings, Richard H.
Tetrahedron, 1993 , vol. 49, # 9 p. 1807 - 1820
反应条件
chlorosulfonic acid
T=0 - 20°C; 8 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/4960 A1, 2007 ;
Location in patent: Page/Page column 29-30 ;
WO 2007/004960 A1
反应条件
1: 92 percent / NaH / dimethylformamide / 20 °C
2: 65 percent / O3 / CH2Cl2 / -78 °C
View Scheme
参考文献
Forbes, Ian T.; Cooper, David G.; Dodds, Emma K.; Douglas, Sara E.; Gribble, Andrew D.; Ife, Robert J.; Lightfoot, Andrew P.; Meeson, Malcolm; Campbell, Lorraine P.; Coleman, Tanya; Riley, Graham J.; Thomas, David R.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1055 - 1058
