2-(5-甲氧基-2-甲基-1H-吲哚-3-基)-N,N-二甲基乙胺合成路线 （共 8 条）
反应条件
1: With sulfuric acid; acetic acid
T=40 - 60°C; 3.5 - 4.5 h; Heating / reflux;
2: With sodium carbonate in water
pH=10;
参考文献
SUVEN LIFE SCIENCES LIMITED
Patent: WO2004/41781 A1, 2004 ;
Location in patent: Page 11 ;
反应条件
sodium hydroxide; formaldehyd; sodium methylate; sodium cyanoborohydride; acetic acid in methanol
参考文献
Merck Sharp and Dohme Ltd.
Patent: US6187805 B1, 2001 ;
US 6187805 B1
反应条件
sodium methylate; sodium cyanoborohydride; acetic acid in methanol; water
参考文献
Russell; Baker; Barden; Beer; Bristow; Broughton; Knowles; McAllister; Patel; Castro
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3881 - 3895
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Shaw
Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320
Journal of the American Chemical Society, 1956 , vol. 78, p. 6419
反应条件
1: diethyl ether
2: H2O; CHCl3
3: LiAlH4
View Scheme
参考文献
Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374
反应条件
1: H2O; CHCl3
2: LiAlH4
View Scheme
参考文献
Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374
反应条件
1: 195 °C
2: LiAlH4; diethyl ether
View Scheme
参考文献
Shaw
Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320
Journal of the American Chemical Society, 1956 , vol. 78, p. 6419
反应条件
lithium aluminium tetrahydride
参考文献
Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374
