乙基5-苯基-2-(三氟甲基)-3-糠酸酯合成路线 （共 2 条）
反应条件
1: ethyl 4,4,4-trifluoro-3-oxobutanoate With sodium hydride in ethylene glycol dimethyl ether
T=20°C; 0.5 h;
2: 2'-bromoacetophenone in ethylene glycol dimethyl ether
T=20 - 80°C;
3: With toluene-4-sulfonic acid in water; toluene
8 h; Heating / reflux;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1535915 A1, 2005 ;
Location in patent: Page/Page column 61 ;
EP 1535915 A1
反应条件
Rh2(OAc)4 in dichloromethane
Inert atmosphereReflux;
参考文献
Pang, Wan; Zhu, Shifa; Xin, Yong; Jiang, Huanfeng; Zhu, Shizheng
Tetrahedron, 2010 , vol. 66, # 6 p. 1261 - 1266
