(2-氟-3-甲氧基苯基)乙腈合成路线 （共 7 条）
反应条件
in ethanol; water
T=70°C; 16 h;
参考文献
ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
Location in patent: Page/Page column 124 ;
WO 2011/156518 A2
反应条件
in water; N,N-dimethyl-formamide
8 h; Reflux;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; SAKAGUCHI, Hiroshi
Patent: WO2010/24365 A1, 2010 ;
Location in patent: Page/Page column 38-39 ;
反应条件
sodium cyanide in dimethyl sulfoxide
T=90°C; 3 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2005/34939 A1, 2005 ;
Location in patent: Page/Page column 68 ;
反应条件
1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Cooling with ice
2: ethanol; water / 16 h / 70 °C
View Scheme
参考文献
Watanuki, Susumu; Matsuura, Keisuke; Tomura, Yuichi; Okada, Minoru; Okazaki, Toshio; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 1029 - 1037
反应条件
1: sodium tetrahydroborate / ethanol / 2 h / 20 °C
2: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Cooling with ice
3: ethanol; water / 16 h / 70 °C
View Scheme
参考文献
Watanuki, Susumu; Matsuura, Keisuke; Tomura, Yuichi; Okada, Minoru; Okazaki, Toshio; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 1029 - 1037
反应条件
1.1: lithium aluminium tetrahydride / diethyl ether / 1.67 h / 0 - 80 °C
1.2: 0 °C
2.1: phosphorus pentachloride / tetrachloromethane / 1.5 h / 20 - 90 °C
3.1: ethanol; water / 16 h / 70 °C
View Scheme
参考文献
ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
WO 2011/156518 A2
反应条件
in ethanol; water
T=70°C; 16 h;
参考文献
Watanuki, Susumu; Matsuura, Keisuke; Tomura, Yuichi; Okada, Minoru; Okazaki, Toshio; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 1029 - 1037
