2-羟基-4-甲氧基苯甲醛合成路线 （共 227 条）
反应条件
piperidine in ethanol 3 h; Reflux;
参考文献
SUN CHEMICAL CORPORATION; ROWATT, Brian; HERLIHY, Shaun; DAVIDSON, Robert
Patent: WO2014/18826 A1, 2014 ;
Location in patent: Page/Page column 16 ;
反应条件
piperidine in ethanol 2 h; Heating;
参考文献
Umeda; Imanishi; Hirai
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 12 p. 3507 - 3513
反应条件
1: With dicyclohexyl-carbodiimide in dimethyl sulfoxide Reflux; 2: With hydrogen iodide; acetic anhydride; acetic acid Reflux;
参考文献
Antonella Fais; Corda, Marcella; Era, Benedetta; Fadda, M. Benedetta; Matos, Marioa Joao; Quezada, Elias; Santana, Lourdes; Picciau, Carmen; Podda, Gianni; Delogu, Giovanna
Molecules, 2009 , vol. 14, # 7 p. 2514 - 2520
反应条件
triethylamine; benzylamine in chloroform T=55°C; 3 h;
参考文献
Wei, Jia; Wang, Pengcheng; Jia, Qianfa; Huang, Jiaoyao; Du, Zhiyun; Zhang, Kun; Wang, Jian
European Journal of Organic Chemistry, 2013 , # 21 p. 4499 - 4502
反应条件
1.1: BuLi / hexane; tetrahydrofuran / 2 h / 0 °C 1.2: 99 percent / hexane; tetrahydrofuran / -78 °C 2.1: 48 percent / K2CO3 / dimethylformamide 3.1: 78 percent / Grubbs second-generation catalyst / CH2Cl2 / 20 °C View Scheme
参考文献
Ishii; Kaneko; Miyazaki; Harayama
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 3100 - 3102
反应条件
1: 2-Hydroxy-4-methoxy-benzaldehyde With sodium methylate in anhydrous xylene T=60°C; 2 h; Inert atmosphere; 2: 2-triphenyl(α-carboxymethylene)phosphorane imidazolide in anhydrous xylene Intramolecular Wittig reaction; 48 h; RefluxInert atmosphere;
参考文献
Upadhyay, Puspesh K.; Kumar, Pradeep
Tetrahedron Letters, 2009 , vol. 50, # 2 p. 236 - 238
反应条件
7-hydroxy-coumarine in N,N-diethylaniline T=210°C; Wittig reaction; 2 h;
参考文献
Starcevic, Stefan; Brozic, Petra; Turk, Samo; Cesar, Jozko; Lanisnik Rizner, Tea; Gobec, Stanislav
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 248 - 261
反应条件
sodium methylate; triphenylphosphine T=80 - 210°C; 5.5 h; Ionic liquid;
参考文献
Valizadeh, Hassan; Vaghefi, Sevil
Synthetic Communications, 2009 , vol. 39, # 9 p. 1666 - 1678
反应条件
1: methyl (triphenylphosphoranylidene)acetate With N-bromosuccinmide in chloroform T=-20°C; 0.666667 h; Inert atmosphere; 2: 2-Hydroxy-4-methoxy-benzaldehyde in diphenylether T=80 - 200°C; 3 h; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 6 p. 1046 - 1051
反应条件
1-(2-OPPh2-propyl)-3-methylimidazolium hexafluorophosphate; sodium methylate T=110°C; Horner-Wadsworth-Emmons olefination; 0.166667 h; Ionic liquidMicrowave irradiation;
参考文献
Synthetic Communications, , vol. 39, # 24 p. 4341 - 4349
