2-氰基-3-苯基-丙酸乙酯合成路线 （共 49 条）
反应条件
(i) Na, toluene, (ii) ClO3F; Multistep reaction;
参考文献
Gershon,H. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541
反应条件
1: (i) Na, toluene, (ii) ClO3F 2: aq. NaOH View Scheme
参考文献
Gershon,H. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541
反应条件
sodium hydride 1.) THF, 2.) THF/CH2Cl2 (1:1), 6 h, 0 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 38, # 4 p. 527 - 537
反应条件
potassium hydroxide; acetic acid; sodium nitrite in hydrogenchloride; ethanol; water; benzene
参考文献
Hoffmann-La Roche Inc.
Patent: US4156016 A1, 1979 ;
反应条件
1: Raney-Ni of W-2, NaOAc, hydrogen / acetic anhydride / 12 h / 50 °C / 15514.4 Torr 2: conc. HCl / acetic acid; H2O / 12 h / Heating View Scheme
参考文献
Zon, Jerzy; Laber, Bernd
Phytochemistry (Elsevier), 1988 , vol. 27, # 3 p. 711 - 714
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran Ambient temperature;
参考文献
Kang; Hong; Cho; Koh
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7661 - 7664
反应条件
sodium hydroxide in ethanol; water
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: US4863904 A1, 1989 ;
反应条件
Dowex-50 in water 12 h; Heating;
参考文献
Basu, Manas K.; Sarkar, Dipak C.; Ranu, Brindaban C.
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 627 - 632
反应条件
1: α-cyano-β-phenylpropionic acid ethyl ester With potassium hydride in acetonitrile T=20°C; 0.333333 h; Inert atmosphereGlovebox; 2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium in acetonitrile T=24.84°C; Inert atmosphereGlovebox; Thermodynamic data;
参考文献
Cao, Ying; Zhang, Song-Chen; Zhang, Min; Shen, Guang-Bin; Zhu, Xiao-Qing
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7154 - 7168
反应条件
1: With hydrotalcite; palladium in toluene
T=80°C; 3 h;
2: With hydrogen; hydrotalcite; palladium in toluene
T=80°C; P=760 Torr; 20 h;
参考文献
Motokura, Ken; Fujita, Noriaki; Mori, Kohsuke; Mizugaki, Tomoo; Ebitani, Kohki; Kaneda, Kiyotomi
Tetrahedron Letters, 2005 , vol. 46, # 33 p. 5507 - 5510
