2-氰基-3-苯基-丙酸乙酯合成路线 （共 49 条）
反应条件
3: 19 percent / KH / hexamethylphosphoric acid triamide / 72 h / Ambient temperature
View Scheme
参考文献
Townsend, Craig A.; Theis, Alan B.
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1697 - 1699
反应条件
1.1: 1,2-diamino-benzene; DL-proline / ethanol / 16 h / 20 °C / |Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.25 h / |Inert atmosphere
2.2: 16 h / 35 °C / |Inert atmosphere
3.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 36 h / 20 °C / |Inert atmosphere; |Glovebox; |UV-irradiation
3.2: 0 °C / pH < 3 / |Inert atmosphere
View Scheme
参考文献
Doni, Eswararao; Mondal, Bhaskar; O'Sullivan, Steven; Tuttle, Tell; Murphy, John A.
Journal of the American Chemical Society, 2013 , vol. 135, # 30 p. 10934 - 10937
参考文献
Hessler
American Chemical Journal, 1899 , vol. 22, p. 171
Journal of the American Chemical Society, 1913 , vol. 35, p. 990;38,909
参考文献
Sommer, R.; Mueller, E.; Neumann, W. P.
Liebigs Annalen der Chemie, 1969 , vol. 721, p. 1 - 13
Full Text Show Details
Gmelin Handbook: Sn: Org.Comp.12, 1.4.1.1.1.5.2.2, page 97 - 113
反应条件
1.1: 1,2-diamino-benzene; DL-proline / ethanol / 16 h / 20 °C / |Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.25 h / |Inert atmosphere
2.2: 16 h / 35 °C / |Inert atmosphere
3.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 36 h / 20 °C / |Inert atmosphere; |Glovebox; |UV-irradiation
3.2: 0 °C / pH < 3 / |Inert atmosphere
View Scheme
参考文献
Doni, Eswararao; Mondal, Bhaskar; O'Sullivan, Steven; Tuttle, Tell; Murphy, John A.
Journal of the American Chemical Society, 2013 , vol. 135, # 30 p. 10934 - 10937
反应条件
in acetonitrile
T=20°C; Reduction; oxidation; 24 h; Kinetics; Further Variations:Temperatures;
参考文献
Zhu, Xiao-Qing; Zou, Hong-Ling; Yuan, Ping-Wei; Cao, Lei; Cheng, Jin-Pei
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 9 p. 1857 - 1861
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.25 h / |Inert atmosphere
1.2: 16 h / 35 °C / |Inert atmosphere
2.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 36 h / 20 °C / |Inert atmosphere; |Glovebox; |UV-irradiation
2.2: 0 °C / pH < 3 / |Inert atmosphere
View Scheme
参考文献
Doni, Eswararao; Mondal, Bhaskar; O'Sullivan, Steven; Tuttle, Tell; Murphy, John A.
Journal of the American Chemical Society, 2013 , vol. 135, # 30 p. 10934 - 10937
反应条件
1: 2,3-dihydro-2-phenyl-1H-benzoimidazole / Heating
View Scheme
参考文献
Kumar, Satish; Kapoor, Kamal K.
Synlett, 2007 , # 18 p. 2809 - 2814
反应条件
n-butyllithium
1) THF, hexane, -65 deg C, 2) THF, r.t., 1 d; Yield given. Multistep reaction;
参考文献
Sommer, Andreas; Stamm, Helmut
Liebigs Annalen der Chemie, 1992 , # 2 p. 99 - 102
反应条件
sodium hydride
1.) EtOH; 2.) DMSO, 60 deg C, 28 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Katritzky, Alan R.; Aurrecoechea, Jose M.
Synthesis, 1987 , # 4 p. 342 - 345
