tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.25 h;

copper(l) iodide; Pd2(PPh3)2Cl2; diethylamine T=20°C; Inert atmosphere;

1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C View Scheme

piperidine; sodium sulfate; trifluoroacetic acid; copper(ll) bromide in 1,2-dichloro-ethane 1 h; Inert atmosphereReflux;