3-氨基-4-环丙基-1H-吡唑合成路线 （共 3 条）
反应条件
hydrazine hydrate; acetic acid in ethanol Reflux;
参考文献
Frey, Robin R.; Curtin, Michael L.; Albert, Daniel H.; Glaser, Keith B.; Pease, Lori J.; Soni, Niru B.; Bouska, Jennifer J.; Reuter, David; Stewart, Kent D.; Marcotte, Patrick; Bukofzer, Gail; Li, Junling; Davidsen, Steven K.; Michaelides, Michael R.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3777 - 3787
反应条件
1: With sodium in diethyl ether T=20°C; 48 h; Industry scaleCooling with ice; 2: With acetic acid in diethyl ether T=10 - 12°C; 3: With hydrazine in tetrahydrofuran 2 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MUELLER, Stephan-Georg; BROWN, Christoper, John; HEIFETZ, Alexander; NOSSE, Bernd; PRESTLE, Juergen; PREVOST, Natacha; RUDOLF, Klaus; SCHEUERER, Stefan; SCHINDLER, Marcus; STENKAMP, Dirk; THOMAS, Leo; TYE, Heather
Patent: WO2010/60952 A1, 2010 ;
Location in patent: Page/Page column 114 ;
WO 2010/060952 A1
反应条件
1: With sodium; formic acid ethyl ester in diethyl ether T=20°C; 97 h; 2: With acetic acid T=10 - 15°C; 0.5 h;
参考文献
WO2004/844 A1, ;
Page 105,106 ;
