2-叔丁氧羰基氨基乙硫醇合成路线 （共 12 条）
反应条件
1: 2-mercaptoethanamine hydrochloride With sodium hydride in tetrahydrofuran T=0 - 20°C; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=0 - 20°C;
参考文献
Kim, Young Zu; Kim, Jae Pil
Synthetic Communications, 2002 , vol. 32, # 10 p. 1601 - 1605
反应条件
hydrogen; [Rh(H)(PEt3)3] in toluene 0.5 h; Heating;
参考文献
Arisawa, Mieko; Sugata, Chiyoshi; Yamaguchi, Masahiko
Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6097 - 6099
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; hydridotetrakis(triphenylphosphine)rhodium (Ph3P)4RhH in acetone 1 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 127, # 35 p. 12226 - 12227
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=0°C; 0.5 h;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 24 p. 2571 - 2574
反应条件
sodium methylate in methanol T=20°C; 0.25 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 10 p. 2742 - 2746
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Simons, Stoney S.; Pons, Michel; Johnson, David F.
Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 3084 - 3088
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 20 °C 2: Dithiothreitol / N,N-dimethyl-formamide / 12 h / 90 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 2 p. 769 - 772
反应条件
in chloroform T=20°C; 96 h;
参考文献
SHIRE HUMAN GENETIC THERAPIES, INC.; HEARTLEIN, Michael; GUILD, Braydon, Charles; DEROSA, Frank; ZHANG, Jerry, Chi
Patent: WO2012/170889 A1, 2012 ;
Location in patent: Page/Page column 62-64 ;
反应条件
sodium hydroxide in water; acetonitrile T=20°C; pH=11.4; 24 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 135, # 9 p. 3539 - 3549
反应条件
1: 2-[(tert-butoxycarbonyl)amino]-1-ethanethiol With sodium hydride in tetrahydrofuran T=20°C; 1 h; Cooling with iceInert atmosphere; 2: methyl iodide in tetrahydrofuran T=20°C; 1 h; Cooling with ice;
参考文献
QILU Pharmaceutical Co., Ltd.
Patent: US2012/208833 A1, 2012 ;
Location in patent: Page/Page column 11 ;
