R-alpha-氨基-4-甲氧基苯乙酰胺合成路线 (共 5 条)
反应条件
triethylamine in N,N-dimethyl-formamide T=5 - 7°C; 1.5 h;
参考文献
Wyeth
Patent: US2007/299120 A1, 2007 ;
Location in patent: Page/Page column 32 ;
反应条件
1: NH3; EDC
2: H2 / Pd(OH)2
View Scheme
参考文献
Washburn; Sun; Bisacchi; Wu; Cheng; Sher; Ryono; Gavai; Poss; Girotra; McCann; Mikkilineni; Dejneka; Wang; Merchant; Morella; Arbeeny; Harper; Slusarchyk; Skwish; Russell; Allen; Tesfamariam; Frohlich; Abboa-Offei; Cap; Waldron; George; Young; Dickinson; Seymour
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 13 p. 3525 - 3529
反应条件
1: NH4Cl
2: 11 percent / Rhodococcus sp. AJ270 / aq. phosphate buffer / 3.5 h / 30 °C / pH 7.62
View Scheme
参考文献
Wang, Mei-Xiang; Lin, Shuang-Jun
Tetrahedron Letters, 2001 , vol. 42, # 39 p. 6925 - 6927
反应条件
potassium phosphatr buffer; Rhodococcus sp.AJ270 cells
T=30°C; pH=7.0; 2 h; Enzymatic reaction;
参考文献
Wang, Mei-Xiang; Lin, Shuang-Jun
Journal of Organic Chemistry, 2002 , vol. 67, # 18 p. 6542 - 6545
反应条件
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Lopata, Antal; Faigl, Ferenc; Fogassy, Elemer; Darvas, Ferenc
Journal of Chemical Research, Miniprint, 1984 , # 10 p. 2930 - 2952