1-(2,3,5-三-O-乙酰基-beta-D-阿拉伯呋喃糖基)-4-氨基嘧啶-2(1H)-酮合成路线 （共 10 条）
参考文献
Saladino, Raffaele; Mincione, Enrico; Crestini, Claudia; Mezzetti, Maurizio
Tetrahedron, 1996 , vol. 52, # 19 p. 6759 - 6780
反应条件
ammonia; 3,3-dimethyldioxirane in dichloromethane; acetone
T=25°C;
参考文献
Saladino, Raffaele; Mincione, Enrico; Crestini, Claudia; Mezzetti, Maurizio
Tetrahedron, 1996 , vol. 52, # 19 p. 6759 - 6780
反应条件
zinc dibromide in methanol; chloroform
Ambient temperature;
参考文献
Bobek; Kavai; Sharma; Grill; Dutschman; Cheng
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2154 - 2157
反应条件
1: 129 g / pyridine / 18 h / 45 °C
2: ZnBr2 / CHCl3; methanol / Ambient temperature
View Scheme
参考文献
Bobek; Kavai; Sharma; Grill; Dutschman; Cheng
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2154 - 2157
反应条件
ammonium hydroxide in 1,4-dioxane
6 h; Ambient temperature;
参考文献
Divakar, K.J.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
反应条件
1: triethylamine / H2O / 5 h / 70 °C
2: 34.7 g / pyridine / 5 h / Ambient temperature
3: 89 percent / acetonitrile / 1.5 h / Ambient temperature
4: aq.ammonia / dioxane / 6 h / Ambient temperature
View Scheme
参考文献
Divakar, K.J.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
反应条件
1: 34.7 g / pyridine / 5 h / Ambient temperature
2: 89 percent / acetonitrile / 1.5 h / Ambient temperature
3: aq.ammonia / dioxane / 6 h / Ambient temperature
View Scheme
参考文献
Divakar, K.J.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
反应条件
1: diphenyl carbonate, sodium hydrogen carbonate / hexamethylphosphoric acid triamide / 0.33 h / 150 °C
2: triethylamine / H2O / 5 h / 70 °C
3: 34.7 g / pyridine / 5 h / Ambient temperature
4: 89 percent / acetonitrile / 1.5 h / Ambient temperature
5: aq.ammonia / dioxane / 6 h / Ambient temperature
View Scheme
参考文献
Divakar, K.J.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
反应条件
1: 89 percent / acetonitrile / 1.5 h / Ambient temperature
2: aq.ammonia / dioxane / 6 h / Ambient temperature
View Scheme
参考文献
Divakar, K.J.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
反应条件
in water; isopropyl alcohol
Irradiation; G-values;
参考文献
ANGIOGENE PHARMACEUTICALS LIMITED; THE GRAY LABORATORY CANCER RESEARCH TRUST
Patent: WO2006/32921 A1, 2006 ;
Location in patent: Page/Page column 25 ;
