2-氯-正甲氧基-正甲基乙酰胺合成路线 （共 26 条）
反应条件
potassium carbonate in dichloromethane; water 12 h; Inert atmosphere;
参考文献
Shen, Zengming; Dornan, Peter K.; Khan, Hasan A.; Woo, Tom K.; Dong, Vy M.
Journal of the American Chemical Society, 2009 , vol. 131, p. 1077 - 1091
反应条件
potassium carbonate in water
参考文献
MERCK and CO., INC.
Patent: EP851850 B1, 2001 ;
反应条件
pyridine in dichloromethane T=0 - 23°C;
参考文献
WO2008/21213 A1, ;
Page/Page column 148-149 ;
WO 2008/021213 A1
参考文献
Merck and Co., Inc.
Patent: US5786515 A1, 1998 ;
参考文献
Tetrahedron Letters, , vol. 36, # 35 p. 6209 - 6212
反应条件
1: 2-bromo-5-fluoropyridine With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 2.41667 h; 2: chloroacetic acid N-methyl-N-methoxy-amide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water Cooling with ice;
参考文献
MERCK SHARP and DOHME CORP.; GUO, Liangqin; HAGMANN, William, K.; HE, Shuwen; LAI, Zhong; LIU, Jian; NARGUND, Ravi, P.; SHAH, Shrenik, K.; TRUONG, Quang, T.
Patent: WO2011/88025 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;
反应条件
1: phosphonic acid,diphenyl ester With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: chloroacetic acid N-methyl-N-methoxy-amide in tetrahydrofuran T=0 - 20°C;
参考文献
Kojima, Satoshi; Hidaka, Tsugihiko; Ohba, Yuko
Heteroatom Chemistry, 2004 , vol. 15, # 7 p. 515 - 523
反应条件
1: in tetrahydrofuran; diethyl ether T=-78 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water
参考文献
Kolasa, Teodzyj; Patel, Meena; Mortell, Kathleen H.; Matulenko, Mark A.; Hakeem, Ahmed A.; Bhatia, Pramila A.; Wang, Xueqing; Daanen, Jerome F.; Latshaw, Steven P.; Stewart, Andrew O.
Patent: US2005/176727 A1, 2005 ;
Location in patent: Page/Page column 32 ;
反应条件
hydrogenchloride; n-butyllithium in hexane; tert-butyl methyl ether T=-78 - -65°C; 2 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 8, # 4 p. 587 - 592
反应条件
1: 5-bromo-2-(2,5-dimethyl-pyrrol-1-yl)-pyridine With n-butyllithium in hexane; tert-butyl methyl ether T=-74 - -69°C; 1.25 h; 2: chloroacetic acid N-methyl-N-methoxy-amide in hexane; tert-butyl methyl ether T=-73 - -67°C; 3.33333 h;
参考文献
WO2006/82511 A1, ;
Page/Page column 6; 37 ;
WO 2006/082511 A1
