反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / |Inert atmosphere; |Cooling with ice 1.2: 0.25 h / 20 °C / |Inert atmosphere 2.1: lithium chloride / water; dimethyl sulfoxide / 150 °C / |Inert atmosphere 3.1: hydrogen / tetrahydrofuran / 1551.49 Torr / |Inert atmosphere 4.1: acetic acid / toluene / 4 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Gonzalez-Lopez De Turiso, Felix; Shin, Youngsook; Brown, Matthew; Cardozo, Mario; Chen, Yi; Fong, David; Hao, Xiaolin; He, Xiao; Henne, Kirk; Hu, Yi-Ling; Johnson, Michael G.; Kohn, Todd; Lohman, Julia; McBride, Helen J.; McGee, Lawrence R.; Medina, Julio C.; Metz, Daniela; Miner, Kent; Mohn, Deanna; Pattaropong, Vatee; Seganish, Jennifer; Simard, Jillian L.; Wannberg, Sharon; Whittington, Douglas A.; Yu, Gang; Cushing, Timothy D.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7667 - 7685