甲基-4,4-二甲氧基-2-(3-硝基苄基亚基)-乙酰乙酸酯合成路线 （共 5 条）
反应条件
morpholine; acetic acid
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 7 p. 1799 - 1807
反应条件
T=95 - 120°C; 8.5 h;
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
反应条件
in isopropyl alcohol cyclocondensation; Hantzsch synthesis; 10 h; Heating;
参考文献
Chudik, Miloslav; Marchalin, Stefan; Pham-Huu, Duy-Phong; Humpa, Otakar; Friedl, Zdenek
Monatshefte fur Chemie, 1999 , vol. 130, # 10 p. 1241 - 1252
反应条件
1: 3 h / 100 - 120 °C 2: 6N HCl / acetone / 3 h / 20 °C View Scheme
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
反应条件
1: 51.1 percent / 8.5 h / 95 - 120 °C 2: 95.4 percent / 6 N aq. HCl / acetone / 1 h / Ambient temperature 3: 1.) NH2OH*HCl, NaOAc, 2.) Ac2O / 1.) AcOH, RT, 2.5 h, 2.) AcOH, a) RT, 1.5 h, b) 95 deg C - 100 deg C, 4 h View Scheme
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
