5-氨基-4-氰基-3-(2-甲氧基-2-氧代乙基)噻吩-2-羧酸甲酯合成路线 （共 3 条）
反应条件
morpholine; sulfur in methanol
T=40°C; 2 h; Heating / reflux;
参考文献
Vaysse-Ludot, Lucile; Lecouve, Jean-Pierre; Langlois, Pascal
Patent: US2004/59135 A1, 2004 ;
Location in patent: Page 2 ;
反应条件
sulfur in methanol
Heating / reflux; Product distribution / selectivity;
参考文献
GLENMARK GENERICS LIMITED; KOILPILLAI, Joseph, Prabahar; KULKARNI, Pravin, Bhalchandra; PATIL, Prashant, Bhaskarrao; HIRE, Kapil, Ramesh
Patent: WO2010/21000 A2, 2010 ;
Location in patent: Page 19-20 ;
反应条件
1: methanol / 10 - 70 °C
2: sulfur / methanol / 2 h / 65 - 70 °C
View Scheme
参考文献
FLEMING LABORATORIES LIMITED; BALASUBRAMANIAM, Ravishankar; POLSANI, Pulla Rao; TOGATA, Madduleti
Patent: WO2013/175270 A1, 2013 ;
