2-甲酰基-1-三苯甲基-1H-咪唑合成路线 （共 12 条）
反应条件
1: 2-1H-imidazolcarbaldehyde With triethylamine in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: trityl chloride in N,N-dimethyl-formamide 48 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 5 p. 1483 - 1498
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 0.5 h; 2: With N,N-dimethyl-formamide in tetrahydrofuran; hexanes T=-78°C; 1.66667 h; 3: With ammonium chloride in tetrahydrofuran; hexanes; water
参考文献
WO2008/78291 A1, ;
Page/Page column 67-68 ;
WO 2008/078291 A1
反应条件
n-butyllithium in tetrahydrofuran T=-78°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 7 p. 2212 - 2216
反应条件
triethylamine in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
US2003/229079 A1, ;
Page 34 ;
反应条件
triethylamine in dichloromethane
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 1.2: 0 - 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 - 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 30 p. 6092 - 6099
反应条件
n-butyllithium 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, RT, 4 h; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 903 - 906
反应条件
n-butyllithium in tetrahydrofuran; hexane cooling in a dry ice acetone bath, stoichiometric n-BuLi; Product distribution;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 57 - 59
反应条件
n-butyllithium in tetrahydrofuran; hexane cooling in a dry ice acetone bath, excess n-BuLi; Product distribution;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 57 - 59
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=20°C; 96 h;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 67, # 9 p. 1335 - 1344
