8-乙酰基-7-羟基香豆素合成路线 （共 21 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C; Mitsunobu reaction; 16 h;
参考文献
Maresca, Alfonso; Scozzafava, Andrea; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7255 - 7258
反应条件
in acetone 24 h; Reflux;
参考文献
Amin, Kamilia M.; Eissa, Amal A.M.; Abou-Seri, Sahar M.; Awadallah, Fadi M.; Hassan, Ghaneya S.
European Journal of Medicinal Chemistry, 2013 , vol. 60, p. 187 - 198
参考文献
Limaye; Joshi
Rasayanam, 1941 , vol. 1, p. 225
反应条件
1: 8.5 g / sodium 2: 2.2 g / PCl5 / CCl4 3: 2.0 g / 1M NaOH / dioxane 4: 0.3 g / copper powder / quinoline View Scheme
参考文献
Bhayani; Thakor
Journal of the Indian Chemical Society, 1990 , vol. 67, # 1 p. 71 - 72
反应条件
1: 81 percent / Potassium cabonate, sodium iodide / acetone / 24 h / Heating
2: 1.) 2N NaOH, 2.) 30percent H2O2 / 1.) reflux, 45 min, 2.) 0 deg C, 2 h
3: 91 percent / Potassium carbonate / acetone / Heating
4: 66 percent / various solvent(s) / 3 h / 200 °C
5: 84 percent / CHCl3; pyridine / 25 °C
6: 100 percent / KIO4 / Osmium tetraoxide / ethyl acetate; H2O / 7.5 h
7: Jones reagent / acetone / 0.33 h
8: 99 percent / 1 N HCl / dioxane / 100 °C
View Scheme
参考文献
Confalone, Pat N.; Confalone, Dianne L.
Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1470 - 1473
反应条件
potassium carbonate in acetone
T=20°C; 24 h;
参考文献
Ren, Xinfeng; Chen, Xiaochuan; Peng, Kun; Xie, Xingang; Xia, Yamu; Pan, Xinfu
Tetrahedron Asymmetry, 2002 , vol. 13, # 16 p. 1799 - 1804
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C; 0.5 h;
参考文献
Tanaka, Hitoshi; Ishihara, Masaya; Ichino, Kazuhiko; Ito, Kazuo
Heterocycles, 1987 , vol. 26, # 12 p. 3115 - 3122
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Mitsunobu reaction; 16 h;
参考文献
Maresca, Alfonso; Scozzafava, Andrea; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7255 - 7258
反应条件
1: 94 percent / K2CO3 / acetone / 24 h / 20 °C
2: 94 percent / aq. H2O2; aq. NaOH / dioxane / 0.33 h / 10 °C
3: 90 percent / pyridine / CH2Cl2 / 24 h / 20 °C
View Scheme
参考文献
Tanaka, Hitoshi; Ishihara, Masaya; Ichino, Kazuhiko; Ito, Kazuo
Heterocycles, 1987 , vol. 26, # 12 p. 3115 - 3122
反应条件
1: 91 percent / K2CO3, KI / dimethylformamide; benzene / 6 h / 85 °C
2: 72 percent / p-diisopropylbenzene / 11.5 h / Heating
3: 39 percent / 70percent (v/v) sulfuric acid / 0.42 h
View Scheme
参考文献
Bender; Kanne; Frazier; Rapoport
Journal of Organic Chemistry, 1983 , vol. 48, # 16 p. 2709 - 2719
