4-羟基-6-甲基-2-吡喃酮合成路线 （共 149 条）
反应条件
bis(acetylacetonate)nickel(II)
T=90°C; 8 h;
参考文献
Marquet, J.; Moreno-Manas, M.
Chemistry Letters, 1981 , p. 173 - 176
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; p-toluenesulfonyl chloride in tetrahydrofuran; water
T=60°C;
参考文献
Hu, Yi; Ding, Qiuping; Ye, Shengqing; Peng, Yiyuan; Wu, Jie
Tetrahedron, 2011 , vol. 67, # 38 p. 7258 - 7262
反应条件
1: 78.5 percent / phosphorous tribromide; N,N-dimethylformamide / diethyl ether / 20 h / 60 °C
2: 86 percent / Pd(OAc)2; (2-furyl)3P; Na2CO3 / benzene; ethanol / Heating
View Scheme
参考文献
Marrison, Lester R; Dickinson, Julia M; Fairlamb, Ian J S
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3509 - 3513
反应条件
sodium carbonate; aniline; sodium nitrite in hydrogenchloride; water
参考文献
Rohm and Haas Company
Patent: US4345934 A1, 1982 ;
反应条件
sodium carbonate; aniline; sodium nitrite in hydrogenchloride; water
参考文献
Mojahidi, Souad; Rakib, El Mostapha; Sekkak, Hanan; Abouricha, Said; Benchat, Nouredine; Mousse, Hassan A.; Zyad, Abdelmajid
Archiv der Pharmazie, 2010 , vol. 343, # 5 p. 310 - 313
反应条件
1: 70 percent / POCl3; PCl5 / 4 h / Heating
2: 93 percent / diethyl ether / 24 h / 20 °C
View Scheme
参考文献
Lokot; Pashkovskii; Lakhvich
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 9 p. 1350 - 1354
反应条件
n-butyllithium
Multistep reaction;
参考文献
Groutas, William C.; Stanga, Michael A.; Brubaker, Michael J.; Huang, Tien L.; Moi, Min K.; Carroll, Robert T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1106 - 1109
反应条件
n-butyllithium
Multistep reaction;
参考文献
Groutas, William C.; Stanga, Michael A.; Brubaker, Michael J.; Huang, Tien L.; Moi, Min K.; Carroll, Robert T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1106 - 1109
反应条件
T=80°C; 2 h; Ionic liquid;
参考文献
Zhang, Xinying; Qu, Yingying; Fan, Xuesen; Wang, Xia; Wang, Jianji
Journal of Chemical Research, 2009 , # 8 p. 473 - 477
反应条件
sodium carbonate in water
T=50°C; 1 h;
参考文献
Shahid, Samina; Mughal, Tahira; Shah, Hamid Ullah
Asian Journal of Chemistry, 2013 , vol. 25, # 2 p. 633 - 636
