4-羟基-6-甲基-2-吡喃酮合成路线 （共 149 条）
反应条件
CoCl2
T=200°C; 0.0833333 h;
参考文献
Marquet, J.; Moreno-Manas, M.
Chemistry Letters, 1981 , p. 173 - 176
反应条件
triethylamine in various solvent(s)
5 h; Heating;
参考文献
Rehse; Schinkel
Archiv der Pharmazie, 1983 , vol. 316, # 12 p. 988 - 994
反应条件
toluene-4-sulfonic acid in benzene
6 h; Heating;
参考文献
Rehse; Schinkel
Archiv der Pharmazie, 1983 , vol. 316, # 12 p. 988 - 994
反应条件
sodium salt of phosphorous acid
T=120°C; 24 h;
参考文献
Rehse; Schinkel
Archiv der Pharmazie, 1983 , vol. 316, # 12 p. 988 - 994
反应条件
n-butyllithium
Multistep reaction;
参考文献
Groutas, William C.; Stanga, Michael A.; Brubaker, Michael J.; Huang, Tien L.; Moi, Min K.; Carroll, Robert T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1106 - 1109
反应条件
1: 1.) BuLi
2: K2CO3 / acetone / Heating
View Scheme
参考文献
Groutas, William C.; Stanga, Michael A.; Brubaker, Michael J.; Huang, Tien L.; Moi, Min K.; Carroll, Robert T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1106 - 1109
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium in tetrahydrofuran
T=-78 - -30°C;
2: ethyl iodide in tetrahydrofuran
T=-78 - 20°C; 12 h;
3: methyl iodide in tetrahydrofuran
T=20°C; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
piperidine; acetic acid in ethanol
24 h; Ambient temperature;
参考文献
March, P. de; Moreno-Manas, M.; Casado, J.; Pleixats, R.; Roca, J. L.; Trius, A.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 1 p. 85 - 89
反应条件
piperidine; acetic acid in ethanol
T=60°C; 15 h;
参考文献
March, P. de; Moreno-Manas, M.; Casado, J.; Pleixats, R.; Roca, J. L.; Trius, A.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 1 p. 85 - 89
反应条件
piperidine; acetic acid in ethanol
参考文献
Moreno-Manas, Marcial; Pleixats, Roser
Synthesis, 1984 , # 5 p. 430 - 431
