4-羟基-6-甲基-2-吡喃酮合成路线 （共 149 条）
反应条件
1: 29 percent / Bu4NBr; P2O5 / toluene / 1 h / 100 °C
2: 90 percent / K3PO4*H2O; SPhos / Pd(OAc)2 / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Marrison, Lester R; Dickinson, Julia M; Fairlamb, Ian J S
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3509 - 3513
反应条件
trifluoroacetic acid
T=100°C; 5 h;
参考文献
Crombie, Leslie; Games, David E.; James, Alun W. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1996 , # 22 p. 2715 - 2724
反应条件
1: pyridine / 20 °C
2: NaSH / ethanol / 2 h / 20 °C
3: aq. NaOH; benzyltriethylammonium chloride / CHCl3 / 4 h / 20 °C
View Scheme
参考文献
Majumdar, Krishna C.; Kundu, Uday K.; Ghosh, Subhojit
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 19 p. 2139 - 2140
反应条件
1: 79 percent / PBr3 / dimethylformamide / 70 °C
2: 82 percent / PPh3; Et3N; CuI / 10 percent Pd/C / acetonitrile / 3 h
View Scheme
参考文献
Battenberg, Oliver A.; Nodwell, Matthew B.; Sieber, Stephan A.
Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 6075 - 6087
反应条件
1: trifluoroacetic acid / 5 h / Heating
2: Et3SiH, LiClO4 / trifluoroacetic acid / 4 h / Ambient temperature
View Scheme
参考文献
Lokot, Igor P.; Pashkovsky, Felix S.; Lakhvich, Fedor A.
Tetrahedron, 1999 , vol. 55, # 15 p. 4783 - 4792
反应条件
potassium carbonate in acetone
Heating;
参考文献
Majumdar; Biswas; Mukhopadhyay
Canadian Journal of Chemistry, 2005 , vol. 83, # 12 p. 2046 - 2051
反应条件
1: pyridine / 20 °C
2: NaSH / ethanol / 2 h / 20 °C
View Scheme
参考文献
Majumdar, Krishna C.; Kundu, Uday K.; Ghosh, Subhojit
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 19 p. 2139 - 2140
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Majumdar; Muhuri
Synthesis, 2006 , # 16 p. 2725 - 2730
反应条件
diethylaluminium chloride in hexane; dichloromethane
T=20°C; 24 h;
参考文献
Hagiwara, Hisahiro; Miya, Shigeki; Suzuki, Toshio; Ando, Masayoshi; Yamamoto, Isao; Kato, Michiharu
Heterocycles, 1999 , vol. 51, # 3 p. 493 - 496
反应条件
sodium hydroxide
Ambient temperatureelectrolysis;
参考文献
Iguchi, Masanobu; Nishiyama, Atsuko; Eto, Hideo; Yamamura, Shosuke
Chemistry Letters, 1980 , p. 1323 - 1326
反应条件
1: potassium carbonate / acetone / Inert atmosphere; Reflux
2: selenium(IV) oxide / 1,4-dioxane / 5 h / 180 °C / Inert atmosphere; Sealed tube
3: n-butyllithium; triphenyl-methyl-phosphonium iodide / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere
4: sodium acetate; palladium diacetate / acetonitrile / 0.17 h
5: 5 Pd(II)/C(eggshell); hydrogen / methanol / 1.5 h / 20 °C
View Scheme
参考文献
Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.
European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
