4-羟基-6-甲基-2-吡喃酮合成路线 （共 149 条）
反应条件
in water
3 h; Heatingmethylamine excess;
参考文献
Magedov, Igor V.; Manpadi, Madhuri; Evdokimov, Nikolai M.; Elias, Eerik M.; Rozhkova, Elena; Ogasawara, Marcia A.; Bettale, Jennifer D.; Przheval'skii, Nikolai M.; Rogelj, Snezna; Kornienko, Alexander
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 3872 - 3876
反应条件
1: H2O / 1 h / Heating; 1/1 proportion
2: H2O / Heating
View Scheme
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
反应条件
in water
1 h; Heatingalso with other amines, vari. of reaction time; with proporton 1/1 gives hexanamides, with excess amines gives 4-hydroxy-6-methyl-2-pyridones; Product distributionMechanism;
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
反应条件
in water
3 h; Heatingethylamine excess;
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With potassium carbonate
2: benzyl bromide
参考文献
Zhou, Hui; Qiao, Kangjian; Gao, Zhizeng; Meehan, Michael J.; Li, Jesse W.-H.; Zhao, Xiling; Dorrestein, Pieter C.; Vederas, John C.; Tang, Yi
Journal of the American Chemical Society, 2010 , vol. 132, # 13 p. 4530 - 4531
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
Heating;
参考文献
Obata, Toru; Shimo, Tetsuro; Yasutake, Mikio; Shinmyozu, Teruo; Kawaminami, Masaru; Yoshida, Ryosuke; Somekawa, Kenichi
Tetrahedron, 2001 , vol. 57, # 8 p. 1531 - 1541
反应条件
(i) nBuLi, iPr2NH, THF, hexane, (ii) /BRN= 385838/, NaH; Multistep reaction;
参考文献
Stockinger,H.; Schmidt,U.
Justus Liebigs Annalen der Chemie, 1976 , p. 1617 - 1625
反应条件
1: potassium carbonate / acetone / Inert atmosphere; Reflux
2: selenium(IV) oxide / 1,4-dioxane / 5 h / 180 °C / Inert atmosphere; Sealed tube
3: n-butyllithium; triphenyl-methyl-phosphonium iodide / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere
4: sodium acetate; palladium diacetate / acetonitrile / 0.17 h
View Scheme
参考文献
Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.
European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
反应条件
ammonium acetate in water
T=90°C; 0.166667 h; Microwave irradiation;
参考文献
Shi, Feng; Cao, Longji; Ma, Ning; Zhang, Ge; Chen, Rongshun; Zhang, Yajie; Tu, Shujiang
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 1 p. 22 - 25
