4-羟基-6-甲基-2-吡喃酮合成路线 （共 149 条）
反应条件
1: AcOH / dimethylformamide / 0.5 h / 60 °C 2: 37.2 percent / dimethylamineborane / acetic acid / 1 h / Heating View Scheme
参考文献
Ziegler, Erich; Wolfbeis, Otto S.; Trummer, Iris
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982 , vol. 37, # 1 p. 105 - 107
反应条件
tetrabutylammomium bromide; phosphorus pentoxide in toluene T=100°C; 1 h;
参考文献
Kato, Yoshiaki; Okada, Shigemitsu; Tomimoto, Koji; Mase, Toshiaki
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4849 - 4851
反应条件
in water 4 h; Heatingproportion 1/2;
参考文献
Castillo, Simone; Ouadahi, Hamid; Herault, Valentin
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 7-8 p. 257 - 261
反应条件
1: palladium 10 on activated carbon / butan-1-ol / 8 h / 49.84 °C / 15514.9 Torr 2: Amberlyst.(R).-70 / water; tetrahydrofuran / 12 h / 169.84 °C / 15514.9 Torr / Inert atmosphere View Scheme
参考文献
Dumesic, James A.; Chia, Mei
Patent: US2012/116119 A1, 2012 ;
反应条件
1: 53 percent / CF3COOH / 5 h / 100 °C 2: 96 percent / H2O / 3 h / Heating 3: 78 percent / H2O / 60 h / Heating View Scheme
参考文献
Crombie, Leslie; Games, David E.; James, Alun W. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1996 , # 22 p. 2715 - 2724
反应条件
1: 57 percent / POCl3; ZnCl2 / 4 h / 80 - 90 °C 2: 68 percent / I2; NaOAc / acetic acid / Heating View Scheme
参考文献
Zehnder, Luke R.; Dahl, Jason W.; Hsung, Richard P.
Tetrahedron Letters, 2000 , vol. 41, # 12 p. 1901 - 1905
反应条件
1: potassium carbonate / acetone / Inert atmosphere; Reflux 2: selenium(IV) oxide / 1,4-dioxane / 5 h / 180 °C / Inert atmosphere; Sealed tube 3: n-butyllithium; triphenyl-methyl-phosphonium iodide / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere 4: sodium acetate; palladium diacetate / acetonitrile / 0.17 h 5: 5 Pd(II)/C(eggshell); hydrogen / methanol / 1.5 h / 20 °C View Scheme
参考文献
Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.
European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
反应条件
1: potassium carbonate / acetone / Inert atmosphere; Reflux 2: selenium(IV) oxide / 1,4-dioxane / 5 h / 180 °C / Inert atmosphere; Sealed tube 3: n-butyllithium; triphenyl-methyl-phosphonium iodide / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere 4: sodium acetate; palladium diacetate / acetonitrile / 0.17 h View Scheme
参考文献
Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.
European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
反应条件
triethylamine in dichloromethane T=20°C; 0.5 h;
参考文献
Kuroda, Jun-Ichi; Inamoto, Kiyofumi; Hiroya, Kou; Doi, Takayuki
European Journal of Organic Chemistry, 2009 , # 14 p. 2251 - 2261
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: benzyl chloride in tetrahydrofuran; hexane T=20°C; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
