4-羟基-6-甲基-2-吡喃酮合成路线 （共 149 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide 1.) THF, hexane, 0 deg C, 30 min, 2.) THF, hexane, 0 deg C, 60 min; Yield given. Multistep reaction;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: EP1203770 A1, 2002 ;
Location in patent: Page 55 ;
反应条件
in 1,4-dioxane T=20°C; 1 h;
参考文献
Law, Ga-Lai; Man, Cornelia; Parker, David; Walton, James W.
Chemical Communications, 2010 , vol. 46, # 14 p. 2391 - 2393
反应条件
hydrogen; CD; palladium/alumina in acetic acid T=20°C; Catalytic hydrogenation; P=750.06 Torr; 24 h; Product distribution; Further Variations:CatalystsSolventsPressures;
参考文献
Huck; Mallat; Baiker
Journal of Catalysis, 2000 , vol. 193, # 1 p. 1 - 4
反应条件
triethylamine in acetonitrile Heating;
参考文献
Shimo, Tetsuro; Ueda, Shinichi; Suishu, Takaaki; Somekawa, Kenichi
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 727 - 730
反应条件
triethylamine in acetonitrile Heating;
参考文献
Shimo, Tetsuro; Ueda, Shinichi; Suishu, Takaaki; Somekawa, Kenichi
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 727 - 730
参考文献
The Dupont Merck Pharmaceutical Company
Patent: US5583147 A1, 1996 ;
反应条件
1: 1.) NH4OH, 2.) HNO3, 3) POCl3 View Scheme
参考文献
McCarthy, Peter A.; Hamanaka, Ernest S.; Marzetta, Carol A.; Bamberger, Mark J.; Gaynor, B. J.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1252 - 1255
反应条件
trichlorophosphate T=25 - 100°C; 17 h;
参考文献
Fairlamb, Ian J. S.; Lee, Adam F.; Loe-Mie, Faidjiba E. M.; Niemelae, Elina H.; O'Brien, Ciara T.; Whitwood, Adrian C.
Tetrahedron, 2005 , vol. 61, # 41 p. 9827 - 9838
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With lithium diisopropyl amide in tetrahydrofuran; HMPA; hexane T=0°C; 0.5 h; 2: bromomethyl-cyclopropane in tetrahydrofuran; HMPA; hexane T=0 - 20°C;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: EP1203770 A1, 2002 ;
Location in patent: Page 57 ;
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide Metallation; alkylation;
参考文献
Schwartz, Theresa M.; Bundy, Gordon L.; Strohbach, Joseph W.; Thaisrivongs, Suvit; Johnson, Paul D.; Skulnick, Harvey I.; Tomich, Paul K.; Lynn, Janet C.; Chong, Kong Teck; Hinshaw, Roger R.; Raub, Thomas J.; Padbury, Guy E.; Toth, Lisa N.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 4 p. 399 - 402
