4-羟基-6-甲基-2-吡喃酮合成路线 （共 149 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; bis(acetylacetonato) palladium; triphenylphosphine in toluene T=72°C; 1.5 h;
参考文献
Moreno-Manas, Marcial; Ribas, Jordi; Virgili, Albert
Journal of Organic Chemistry, 1988 , vol. 53, # 22 p. 5328 - 5335
反应条件
1: 55 percent / K2CO3 / acetone / 5 h / Heating 2: 65 percent / xylene / 17 h / Heating View Scheme
参考文献
Majumdar, Krishna C.; Ghosh, Subhojit
Monatshefte fur Chemie, 2002 , vol. 133, # 10 p. 1317 - 1323
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; hexane
T=20°C; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
1: 45 percent / 100 °C
2: 48 percent / DMAP / toluene / Heating
3: 95 percent / DDQ
View Scheme
参考文献
Zehnder, Luke R.; Dahl, Jason W.; Hsung, Richard P.
Tetrahedron Letters, 2000 , vol. 41, # 12 p. 1901 - 1905
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: ethyl iodide in tetrahydrofuran; hexane
T=20°C; 12 h; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
n-butyllithium
Multistep reaction;
参考文献
Pharmacia and Upjohn Company
Patent: US5852195 A1, 1998 ;
US 5852195 A
反应条件
1.1: 0.5 h / 80 °C
2.1: butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 4.07 g / tetrahydrofuran; hexane / 20 h / 20 °C
View Scheme
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
1: 70 percent / POCl3; PCl5 / 4 h / Heating
2: 93 percent / diethyl ether / 24 h / 20 °C
View Scheme
参考文献
Lokot; Pashkovskii; Lakhvich
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 9 p. 1350 - 1354
反应条件
lithium perchlorate
electrolysis;
参考文献
Iguchi, Masanobu; Nishiyama, Atsuko; Eto, Hideo; Yamamura, Shosuke
Chemistry Letters, 1980 , p. 1323 - 1326
反应条件
in methanol
Ambient temperatureelectrolysis; Yield given;
参考文献
Iguchi, Masanobu; Nishiyama, Atsuko; Eto, Hideo; Yamamura, Shosuke
Chemistry Letters, 1980 , p. 1323 - 1326
