3,7,11-三甲基-1-十二烷醇合成路线 （共 9 条）
反应条件
Pt/Al2O3; lithium aluminium tetrahydride T=250°C; Hydrogenolysis; 0.666667 h;
参考文献
Aldrich, J. R.; Oliver, J. E.; Lusby, W. R.; Kochansky, J. P.; Borges, M.
Journal of Chemical Ecology, 1994 , vol. 20, # 5 p. 1103 - 1112
反应条件
1: HBr / heptane 2: (i) Mg, Et2O, (ii) /BRN= 505984/ 3: benzene 4: (i) (pyrolysis), (ii) H2, PtO2, EtOH View Scheme
参考文献
McCarthy,E.D.; Calvin,M.
Tetrahedron, 1967 , vol. 23, p. 2609 - 2619
反应条件
1: 83 percent / triethylamine / CH2Cl2 / 0.5 h / -5 °C 2: 70 percent / benzene / 10 h / Heating 3: 60 percent / KOH / methanol; H2O / 4 h / Heating 4: 80 percent / tetrahydrofuran / 1.) r.t. 2.) reflux 2 h View Scheme
参考文献
Julia; Uguen
Bulletin de la Societe Chimique de France, 1976 , vol. II, # 3-4 p. 513 - 518
反应条件
1: 83 percent / triethylamine / CH2Cl2 / 0.5 h / -5 °C 2: 70 percent / benzene / 10 h / Heating 3: 60 percent / KOH / methanol; H2O / 4 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 19, # 6 p. 453 - 455
反应条件
1: H2SO4, aq. HBr / Heating 2: (i) Mg, (ii) /BRN= 1634534/, (iii) KHSO4 3: (hydrogenation) 4: (i) nBuLi, (ii) /BRN= 1724987/, (iii) H2 View Scheme
参考文献
Journal of the Chemical Society, , p. 5706 - 5713
反应条件
1: 87 percent / hydrogen bromide 2: 76 percent / magnesium / tetrahydrofuran / Heating 3: 95 percent / copper(I) iodide / tetrahydrofuran; various solvent(s) / 24 h / -20 - 0 °C View Scheme
参考文献
Fujisawa, Tamotsu; Sato, Toshio; Kawara, Tatsuo; Ohashi, Kazuo
Tetrahedron Letters, 1981 , vol. 22, # 48 p. 4823 - 4826
反应条件
Jone's reagent in isopropyl alcohol; acetone T=0°C; 4 h; Inert atmosphere;
参考文献
Munoz, Lourdes; Guerrero, Angel
Synthesis, 2012 , vol. 44, # 6 p. 862 - 864
反应条件
2: 400 °C
View Scheme
参考文献
AMYRIS, INC.; OHLER, Nicholas; FISHER, Karl; HONG, Jin Ki
Patent: WO2012/141783 A1, 2012 ;
反应条件
1: 83 percent / triethylamine / CH2Cl2 / 0.5 h / -5 °C
2: 70 percent / benzene / 10 h / Heating
3: 60 percent / KOH / methanol; H2O / 4 h / Heating
4: 80 percent / tetrahydrofuran / 1.) r.t. 2.) reflux 2 h
5: 72 percent / 1) PTS monohydrate / acetic acid / 1.) 30 min, 0 deg C 2.) 30 min, r.t.
View Scheme
参考文献
Vig, O. P.; Bari, S. S.; Vig, Rashmi; Dua, D. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 6 p. 453 - 455
