N-Boc-4,4-二氟环已胺合成路线 （共 13 条）
反应条件
1: Dess-Martin periodane / dichloromethane / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
反应条件
1: triethylamine / tetrahydrofuran / 20 °C
2: Dess-Martin periodane / dichloromethane / 20 °C
3: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
反应条件
1: triethylamine / tetrahydrofuran / 20 °C
2: Dess-Martin periodane / dichloromethane / 20 °C
3: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
