2-甲基-2-丙基(4-氟-3-环己烯-1-基)氨基甲酸酯合成路线 （共 6 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/24728 A2, 2004 ;
Location in patent: Page 113 ;
WO 2004/024728 A2
反应条件
diethylamino-sulfur trifluoride in dichloromethane
T=-5 - 20°C; Inert atmosphere;
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
Location in patent: Page/Page column 64 ;
反应条件
1: Dess-Martin periodane / dichloromethane / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
反应条件
1: triethylamine / tetrahydrofuran / 20 °C
2: Dess-Martin periodane / dichloromethane / 20 °C
3: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
反应条件
1: triethylamine / tetrahydrofuran / 20 °C
2: Dess-Martin periodane / dichloromethane / 20 °C
3: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
反应条件
sodium tetrahydroborate; diethylamino-sulfur trifluoride; 3-chloro-benzenecarboperoxoic acid in methanol; water; ethyl acetate; Petroleum ether
参考文献
AGIOS PHARMACEUTICALS, INC; Lemieux, Rene M.; Popovici-Muller, Janeta; Travins, Jeremy; Cai, Zhenwei; Cui, Dawei; Zhou, Ding
Patent: US2013/190249 A1, 2013 ;
Location in patent: Page/Page column ;
