(1R,4S)-4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺盐酸盐(1:1)合成路线 （共 3 条）
反应条件
hydrogenchloride; water in isopropyl alcohol T=110°C; 120 h; optical yield given as percent ee;
参考文献
Thalen, Lisa K.; Zhao, Dongbo; Sortais, Jean-Baptiste; Paetzold, Jens; Hoben, Christine; Baeckvall, Jan-E.
Chemistry - A European Journal, 2009 , vol. 15, # 14 p. 3403 - 3410
反应条件
hydrogenchloride; methanol; water T=20 - 80°C; 3 h; Product distribution / selectivity;
参考文献
WO2007/6003 A2, ;
Page/Page column 26; 29 ;
反应条件
1: titanium tetraethoxide / tetrahydrofuran; ethanol / 70 °C / |Inert atmosphere; |Large scale 2: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran; toluene / -10 - 5 °C / |Inert atmosphere; |Large scale 3: hydrogenchloride / tetrahydrofuran; toluene; methanol / |Inert atmosphere; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 4 p. 726 - 730
