4-氟-3-(三氟甲基)苯甲酸合成路线 （共 5 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
Asahi Kasei Pharma Corporation
Patent: US2008/200535 A1, 2008 ;
Location in patent: Page/Page column 158 ;
US 20080200535 A1
反应条件
thionyl chloride in N,N-dimethyl-formamide; toluene
参考文献
Amato, George; Roeloffs, Rosemarie; Rigdon, Greg C.; Antonio, Brett; Mersch, Theresa; McNaughton-Smith, Grant; Wickenden, Alan D.; Fritch, Paul; Suto, Mark J.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 6 p. 481 - 484
反应条件
in methanol; diethyl ether; dichloromethane T=0°C; 0.333333 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/140342 A1, 2009 ;
Location in patent: Page/Page column 130 ;
WO 2009/140342 A1
反应条件
thionyl chloride in methanol
参考文献
Sanofi-Aventis Deutschland GmbH
Patent: US2007/270414 A1, 2007 ;
反应条件
thionyl chloride T=60°C; 8 h;
参考文献
SANOFI-AVENTIS DEUTSCHLAND GMBH
Patent: WO2006/50830 A1, 2006 ;
Location in patent: Page/Page column 47 ;
