4-氟-3-三氟甲基苯甲腈合成路线 （共 3 条）
反应条件
hydrogenchloride; sodium hydrogencarbonate; sodium nitrite 2.) 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Synthetic Communications, , vol. 26, # 8 p. 1575 - 1578
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1.5 - 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: sodium hydroxide; water / ethanol / 18 h / 80 °C View Scheme
参考文献
Glaxo Group Limited
Patent: US2011/269738 A1, 2011 ;
Title/Abstract Full Text Show Details
GLAXO GROUP LIMITED; DENG, Guanghui; LIN, Xichen; REN, Feng; ZHAO, Baowei
Patent: WO2011/134280 A1, 2011 ;
WO 2011/134280 A1
反应条件
in dimethyl sulfoxide
T=80°C; 22 h;
参考文献
RESPIRATORIUS AB
Patent: US2012/40942 A1, 2012 ;
Location in patent: Page/Page column 36-37 ;
