5-氨基吡啶-2-甲酸甲酯合成路线 （共 7 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol P=760.051 Torr; 12 h;
参考文献
Stover, James S.; Shi, Jin; Jin, Wei; Vogt, Peter K.; Boger, Dale L.
Journal of the American Chemical Society, 2009 , vol. 131, p. 3342 - 3348
反应条件
thionyl chloride Reflux;
参考文献
Kim, Hee Jin; Jung, Myung-Ho; Kim, Hwan; El-Gamal, Mohammed I.; Sim, Tae Bo; Lee, So Ha; Hong, Jun Hee; Hah, Jung-Mi; Cho, Jung-Hyuck; Choi, Jung Hoon; Yoo, Kyung Ho; Oh, Chang-Hyun
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 413 - 417
反应条件
diazomethyl-trimethyl-silane in methanol; diethyl ether; benzene T=0 - 20°C; 6 h;
参考文献
WO2009/26204 A1, ;
Page/Page column 43 ;
WO 2009/026204 A1
反应条件
in tetrafluoroboric acid; ethanol; n-heptane; water
参考文献
American Cyanamid Company
Patent: US4638068 A1, 1987 ;
反应条件
sodium periodate; iodine in N,N-dimethyl-formamide
T=60°C;
参考文献
Kim, Hee Jin; Jung, Myung-Ho; Kim, Hwan; El-Gamal, Mohammed I.; Sim, Tae Bo; Lee, So Ha; Hong, Jun Hee; Hah, Jung-Mi; Cho, Jung-Hyuck; Choi, Jung Hoon; Yoo, Kyung Ho; Oh, Chang-Hyun
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 413 - 417
反应条件
1: in tetrahydrofuran
T=0 - 5°C; 0.25 h; Inert atmosphere;
2: With lithium aluminium tetrahydride
T=20°C; 1 h; Inert atmosphere;
参考文献
PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert; VERNER, Erik
Patent: WO2012/158785 A1, 2012 ;
Location in patent: Page/Page column 102 ;
WO 2012/158785 A1
反应条件
hydrogen bromide; dihydrogen peroxide in water
T=20°C; 3 h;
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1479680 A1, 2004 ;
Location in patent: Page 49 ;
EP 1479680 A1
