3-氨基-1H-吡唑并[3,4-b]吡啶合成路线 （共 5 条）
反应条件
hydrazine in ethanol T=170°C; 0.166667 h; Microwave irradiation;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/59219 A1, 2007 ;
Location in patent: Page/Page column 56 ;
WO 2007/059219 A1
反应条件
1: POCl2 / 6 h / Heating 2: 88 percent / hydrazine hydrate / ethanol / 10 h / Heating View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 66, # 3 p. 420-428
反应条件
1: CHMe2CH2CH2NO2; tetrafluoroboric acid / methanol / 0 - 5 °C 2: hypophosphorous acid / water / 20 °C 3: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C View Scheme
参考文献
Ye, Qing; Shen, Yanhong; Zhou, Yubo; Lv, Dan; Gao, Jianrong; Li, Jia; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 361 - 371
反应条件
1: With tetrafluoroboric acid; CHMe2CH2CH2NO2 in methanol T=0 - 5°C; 2: With hypophosphorous acid in water T=20°C;
参考文献
Ye, Qing; Shen, Yanhong; Zhou, Yubo; Lv, Dan; Gao, Jianrong; Li, Jia; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 361 - 371
反应条件
tetrafluoroboric acid; CHMe2CH2CH2NO2 in methanol
T=0 - 5°C;
参考文献
Ye, Qing; Shen, Yanhong; Zhou, Yubo; Lv, Dan; Gao, Jianrong; Li, Jia; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 361 - 371
