3-甲氧基-4-硝基苯甲酰氯合成路线 （共 19 条）
反应条件
2: 5 g / 85 °C / Hofmann rearrangement View Scheme
参考文献
Shine, Henry J.; Park, Koon Ha; Brownawell, Marilyn L.; Filippo, Joseph San
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7077 - 7082
反应条件
1: in tetrahydrofuran; diethyl ether; acetonitrile T=20°C; 1 h; 2: With hydrogen bromide in tetrahydrofuran; diethyl ether; water; acetonitrile 0.25 h; 3: With water; potassium carbonate in tetrahydrofuran; diethyl ether; acetonitrile
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/26046 A1, 2008 ;
Location in patent: Page/Page column 32 ;
WO 2008/026046 A1
反应条件
1: (i) Mg, (ii) H2SO4, AcOH 2: Br2 / acetic acid View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: ammonium hydroxide / water; tetrahydrofuran / 0.5 h / 0 °C 2: sodium tetrahydroborate; NiII chloride hexahydrate / methanol / 0.5 h / 0 - 23 °C View Scheme
参考文献
WANG, Aihua; Zhang, Yan; Leonard, Kristi Anne; Hawkins, Michael; Tounge, Brett Andrew; Maharoof, Umar S.M.; Barbay, Joseph Kent
Patent: US2012/129811 A1, 2012 ;
反应条件
1: ammonia / methanol / 72 h / 20 °C 2: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 5 h / 20 °C 3: hydrogen / palladium 10 on activated carbon / ethyl acetate / 0.75 h / 20 °C / 2585.81 Torr View Scheme
参考文献
Bartkovitz, David Joseph; Chu, Xin-Jie; Ding, Qingjie; Graves, Bradford James; Jiang, Nan; Zhang, Jing; Zhang, Zhuming
Patent: US2011/130398 A1, 2011 ;
反应条件
1: NH3 / tetrahydrofuran / 0 °C 2: TFA; Et3N / tetrahydrofuran / 1 h View Scheme
参考文献
Bartkovitz, David Joseph; Chu, Xin-Jie; Ding, Qingjie; Graves, Bradford James; Jiang, Nan; Zhang, Jing; Zhang, Zhuming
Patent: US2011/130398 A1, 2011 ;
反应条件
1: malonic acid dimethyl ester With triethylamine; magnesium chloride in toluene T=20°C; 1.5 h; 2: 4-nitro-3-methoxy-benzoylchloride in toluene 0.75 h; 3: With water in dimethyl sulfoxide Heating;
参考文献
Michaelides, Michael R.; Curtin, Michael L.; Dai, Yujia; Davidsen, Steven K.; Frey, Robin R.; Guo, Yan; Ji, Zhiqin
Patent: US2003/225273 A1, 2003 ;
Location in patent: Page 36 ;
反应条件
(i) Mg, (ii) H2SO4, AcOH; Multistep reaction;
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: pyridine / CHCl3 / 2 h / Heating 2: 65 percent / H2 / 5percent Pd/C / ethyl acetate; ethanol / 5 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 111, # 20 p. 7957 - 7968
反应条件
pyridine in chloroform 2 h; Heating; Yield given;
参考文献
Adams, S. R.; Kao, J. P. Y.; Tsien, R. Y.
Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 7957 - 7968
