3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯合成路线 （共 12 条）
反应条件
hydrazine hydrate; nickel in methanol T=20°C;
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 2: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 3: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 2: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 74.3 percent / sulfuric acid / 2 h / Heating 2: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 3: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 4: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 5: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 4: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
反应条件
1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C 4: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Ries; Mihm; Narr; Hasselbach; Wittneben; Entzeroth; Van Meel; Wienen; Hauel
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4040 - 4051
反应条件
1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
参考文献
Ries; Mihm; Narr; Hasselbach; Wittneben; Entzeroth; Van Meel; Wienen; Hauel
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4040 - 4051
反应条件
1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C 4: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 5: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme
参考文献
Ries; Mihm; Narr; Hasselbach; Wittneben; Entzeroth; Van Meel; Wienen; Hauel
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4040 - 4051
反应条件
in acetic acid 2 h; Heating;
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 90 percent / acetic acid / 2 h / Heating 2: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/44754 A2, 2006 ;
Location in patent: Page/Page column 25-26 ;
