1-(2-羟基-5-(三氟甲基)苯基)乙酮合成路线 （共 6 条）
反应条件
sodium hydride; ethanethiol in N,N-dimethyl-formamide; mineral oil
T=100°C; 0.5 h;
参考文献
Fujimoto, Tatsuhiko; Kunitomo, Jun; Tomata, Yoshihide; Marui, Shogo; Nishiyama, Keiji; Nakashima, Masato; Yoshikubo, Shin-Ichi; Hirai, Keisuke; Hirozane, Mariko
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6414 - 6416
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in toluene
T=100°C;
2: With hydrogenchloride in water; toluene
1.5 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65508 A1, 2008 ;
Location in patent: Page/Page column 24 ;
反应条件
sodium iodide in acetonitrile
参考文献
Central Glass Company, Limited
Patent: US2003/109574 A1, 2003 ;
反应条件
1: trifluorormethanesulfonic acid / 3 h / 20 °C / Inert atmosphere
2: boron trichloride / dichloromethane / 2 h / -78 - 20 °C
View Scheme
参考文献
DOMAIN THERAPEUTICS; PRESTWICK CHEMICAL, INC.; SCHANN, Stephan; MAYER, Stanislas; MORICE, Christophe; GIETHLEN, Bruno
Patent: WO2011/51478 A1, 2011 ;
WO 2011/051478 A1
反应条件
in benzene
5 h; Irradiation;
参考文献
Jimenez, M. Consuelo; Leal, Pablo; Miranda, Miguel A.; Tormos, Rosa
Journal of the Chemical Society, Chemical Communications, 1995 , # 19 p. 2009 - 2010
反应条件
1: potassium carbonate / acetone / 0 °C / Reflux
2: trifluorormethanesulfonic acid / 0 - 20 °C
3: sodium hydride; ethanethiol / N,N-dimethyl-formamide; mineral oil / 0.5 h / 100 °C
View Scheme
参考文献
Fujimoto, Tatsuhiko; Kunitomo, Jun; Tomata, Yoshihide; Marui, Shogo; Nishiyama, Keiji; Nakashima, Masato; Yoshikubo, Shin-Ichi; Hirai, Keisuke; Hirozane, Mariko
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6414 - 6416
