反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere
2: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C
3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Kennedy, Andrew J.; Mathews, Thomas P.; Kharel, Yugesh; Field, Saundra D.; Moyer, Morgan L.; East, James E.; Houck, Joseph D.; Lynch, Kevin R.; MacDonald, Timothy L.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 10 p. 3524 - 3548