3-氨基-5-甲基-吡嗪羧酸合成路线 （共 10 条）
反应条件
1: With sodium hydroxide in water 96 h; Heating / reflux; 2: With hydrogenchloride in water pH=1.5;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2005/95391 A1, 2005 ;
Location in patent: Page/Page column 39 ;
参考文献
Journal of the American Chemical Society, , vol. 80, p. 421,425
参考文献
Journal of the American Chemical Society, , vol. 70, p. 3026,3028
反应条件
1: Raney nickel; ethanol 2: aq. NaOH solution View Scheme
参考文献
Journal of the American Chemical Society, , vol. 80, p. 421,425
参考文献
Journal of the Chemical Society, , p. 4219,4220
参考文献
Journal of Organic Chemistry, , vol. 24, p. 345,348
反应条件
1,2,3,4-tetrahydro-naphthalene 0.5 h; Heating;
参考文献
Rimoli; Avallone; De Caprariis; Luraschi; Abignente; Filippelli; Berrino; Rossi
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 3 p. 195 - 203
反应条件
1: 64 percent / 1,2,3,4-tetrahydro-naphthalene / 1 h / 202 °C 2: bromine, pyridine / CHCl3 / 0.5 h / Ambient temperature; in the dark View Scheme
参考文献
Sato, Nobuhiro
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 143 - 147
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 1.5 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2005/95391 A1, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1: aqueous H2SO4
3: aq.-ethanolic HCl
View Scheme
参考文献
Weijlard et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 802,804
